| 货号 | 1296/50 |
| 别名 | 1-[2-[bis[4-(Trifluoromethyl)phenyl |
| 供应商 | Tocris |
| 生物活性 | Selective inhibitor of the GABA transporter GAT-1 (IC50 values are 0.26 and 1.2 μM at cloned human and rat GAT-1 respectively). Displays over 200-fold selectivity over GAT-2 and GAT-3. Centrally active upon systemic administration in vivo. Anticonvulsive and neuroprotective. |
| 运输条件 | Blue Ice |
| 存放说明 | Ambient |
| 纯度 | >98 % |
| 计算分子量 | 509.87 |
| 分子式 | C23H21F6NO3.HCl |
| 可溶性/溶解性 | Soluble to 10 mM in ethanol and to 100 mM in DMSO |
| CAS号 | 110283-66-4 |
| 参考文献 | Bordenet al (1994) Tiagabine, SK&F 89976-A, CI-966, and NNC-711 are selective for the cloned GABA transporter GAT-1. Eur.J.Pharmacol. 269 219. PMID: 7851497. Radulovicet al (1993) Pharmacokinetics, mass balance, and induction potential of novel GABA uptake inhibitor, CI-966 HCl, in laboratory animals. Pharm.Res. 10 1442. PMID: 8272405. Ebertet al (1990) Systemic CI-966, a new gamma-aminobutyric acid uptake blocker, enhances gamma-aminobutyric acid action in CA1 pyramidal layer in situ. Can.J.Physiol.Pharmacol. 68 1194. PMID: 2276082. |