| 货号 | 2942/50 |
| 别名 | 3-(1,3-Benzodioxol-5-yl)-5-hydroxy- |
| 供应商 | Tocris |
| 生物活性 | Highly selective, orally active, non-peptide endothelin-A receptor (ETA) antagonist (IC50 values are 0.3 and 480 nM for ETA and ETB receptors respectively). Antihypertensive; blocks ET-1-induced pressor responses following oral administration. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 纯度 | >98 % |
| 计算分子量 | 506.5 |
| 分子式 | C28H26O9 |
| 可溶性/溶解性 | Soluble to 50 mM in DMSO |
| CAS号 | 162256-50-0 |
| 参考文献 | Coeet al (2002) The endothelin A receptor antagonists PD 156707 (CI-1020) and PD 180988 (CI-1034) reverse the hypoxic pulmonary vasoconstriction in ther perinatal lamb. J.Pharmacol.Exp.Ther. 302 672. PMID: 12130731. Joneset al (1999) The effect of the endothelin ETA receptor antagonist CI-1020 on hypoxic pulmonary vasoconstriction. Eur.J.Pharmacol. 374 367. PMID: 10422781. Dohertyet al (1995) Discovery of a novel series of orally active non-peptide endothelin-A (ETA) receptor-selective antagonists. J.Med.Chem. 38 1259. PMID: 7731010. |