| 货号 | 1412/50 |
| 别名 | trans-N-[6-Cyano-3,4-dihydro-3-hydr |
| 供应商 | Tocris |
| 生物活性 | Blocker of the slow delayed rectifier K+ current (IKs) (IC50 = 1-10 μM). Also blocks the CFTR chloride current (ICFTR) (IC50 = 19 μM). (-)-[3R,4S]-Chromanol 293B (Cat. No. 1475) also available. |
| 运输条件 | Blue Ice |
| 存放说明 | Ambient |
| 纯度 | >99 % |
| 计算分子量 | 324.39 |
| 分子式 | C15H20N2O4S |
| 可溶性/溶解性 | Soluble to 20 mM in ethanol and to 100 mM in DMSO |
| CAS号 | 163163-23-3 |
| 参考文献 | Bachmannet al (2001) Chromanol 293B, a blocker of the slow delayed rectifier K+ current (IKS), inhibits the CFTR Cl- current. Naunyn Schmiedebergs Arch.Pharmacol. 363 590. PMID: 11414653. Sunet al (2001) Chromanol 293B inhibits slowly activating delayed rectifier and transient outward currents in canine left ventricular myocytes. J.Cardiovasc.Electrophysiol. 12 472. PMID: 11332571. Fujisawaet al (2000) Time-dependent block of the slowly activating delayed rectifier K+ current by chromanol 293B in guinea-pig ventricular cells. Br.J.Pharmacol. 129 1007. PMID: 10696102. |