| 货号 | 3936/50 |
| 别名 | 4-[(2R)-2-[3-(Cyclopentyloxy)-4-met |
| 供应商 | Tocris |
| 生物活性 | Potent and selective inhibitor of phosphodiesterase (PDE) 4 (IC50 = 12 nM for native PDE4). Competitively inhibits all PDE4 isoenzymes (IC50 values are 4, 9, 9 and 45 nM for PDE4A, PDE4B, PDE4C and PDE4D human recombinant isoforms expressed in yeast). |
| 运输条件 | Blue Ice |
| 存放说明 | Ambient |
| 纯度 | >98 % |
| 计算分子量 | 409.95 |
| 分子式 | C25H27NO2.HCl |
| 可溶性/溶解性 | Soluble to 100 mM in DMSO |
| 参考文献 | Cooperet al (1999) A comparison of the inhibitory activity of PDE4 inhibitors on leukocyte PDE4 activity in vitro and eosinophil trafficking in vivo. Br.J.Pharmacol. 126 1863. PMID: 10372831. Perryet al (1998) CDP840: a novel inhibitor of PDE-4. Cell Biochem.Biophys. 29 113. PMID: 9631241. Hugheset al (1996) The inhibition of antigen-induced eosinophilia and bronchoconstriction by CDP840, a novel stereo-selective inhibitor of phosphodiesterase type 4. Br.J.Pharmacol. 118 1183. PMID: 8818342. |