BMS 566419 (50 MG)
货号：
5492/50 基本售价：
11381.8 元 规格：
50 mg
产品信息
概述| 货号 | 5492/50 |
| 别名 | N-[1-[6-(4-Ethyl-1-piperazinyl)-3-pyridinyl]-1-methylethyl]-2-fluoro-9,10-dihydro-9-oxo-3-acridinecarboxamide |
性能| 供应商 | Tocris |
| 生物活性 | Potent inosine monophosphate dehydrogenase (IMPDH) inhibitor (IC50 = 17 nM). Inhibits proliferation of human T-lymphoblasts and PBMCs in vitro. Reduces paw swelling in a rat adjuvant arthritis model. Orally available. |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 纯度 | >98 % |
| 计算分子量 | 487.57 |
| 分子式 | C28H30FN5O2< |
| 可溶性/溶解性 | Soluble to 50 mM in 1eq. HCl and to 100 mM in DMSO |
| 参考文献 | Wattersonet al (2007) Acridone-based inhibitors of inosine 5'-monophosphate dehydrogenase: discovery and SAR leading to the identification of N-(2-(6-(4-ethylpiperazin-1-yl)pyridin-3-yl)propan-2-yl)-2- fluoro-9-oxo-9,10-dihydroacridine-3-carboxamide (BMS-566419). J.Med.Chem. 50 3730. PMID: 17585753. |
