| 货号 | 4357/50 |
| 别名 | 1-(4-Methylphenyl)-3-azabicyclo[3.1 |
| 供应商 | Tocris |
| 生物活性 | Potent antagonist of the noradrenalin transporter (IC50 = 55 nM); also displays antagonist activity at the 5-HT and dopamine transporters (IC50 values are 117 nM and 910 nM respectively). Orally active. Exhibits antinociceptive and antiallodynic activity in rodent models of acute, persistent, and chronic pain. |
| 运输条件 | Blue Ice |
| 存放说明 | Ambient |
| 纯度 | >98 % |
| 计算分子量 | 209.72 |
| 分子式 | C12H15N.HCl |
| 可溶性/溶解性 | Soluble to 100 mM in water and to 100 mM in DMSO |
| 参考文献 | Basile (2007) Characterization of the antinociceptive actions of bicifadine in models of acute, persistent, and chronic pain. J.Pharmacol.Exp.Ther 321 (3) 1208. PMID: 17325229. Epstein (1981) 1-Aryl-3-azabicyclo[3.1.0]hexanes, a new series of nonnarcotic analgesic agents. J.Med.Chem. 24 (5) 481. PMID: 7241504. |