| 货号 | 3314/50 |
| 别名 | 4-(2,3-Dihydro-1,4-benzodioxin-6-yl |
| 供应商 | Tocris |
| 生物活性 | Competitive c-Jun N-terminal kinase (JNK) inhibitor (IC50 = 280 nM) that displays > 100 fold selectivity over p38α and no activity at mTOR and PI-3K. Inhibits JNK interacting protein 1 (JIP1)-JNK binding (IC50 = 500 nM) and prevents JNK substrate phosphorylation. Blocks JNK-dependent Con A-induced liver damage and restores insulin sensitivity in a mouse model of type II diabetes. |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 纯度 | >99 % |
| 计算分子量 | 379.37 |
| 分子式 | C13H9N5O5S2 |
| 可溶性/溶解性 | Soluble to 100 mM in DMSO and to 5 mM in ethanol |
| CAS号 | 883065-90-5 |
| 参考文献 | Flight (2008) Getting rid of JNK. Nat.Rev.Drug Disc. 7975. Haas and Writer (2008) Block JNK at the dock. SCiBX 11. Stebbinset al (2008) Identification of a new JNK inhibitor targeting the JNK-JIP interaction site. Proc.Natl.Acad.Sci.USA 10516809. |