| 货号 | 3317/50 |
| 别名 | 3-[1-[[(3'-Nitro[1,1'-biphenyl]-4-yl) |
| 供应商 | Tocris |
| 生物活性 | Potent and selective human P2X7 antagonist (KB values are 5 - 7 and > 10,000 nM at hP2X7 and rP2X7 respectively) that is completely without effect at all other P2X subtypes. Inhibits BzATP-mediated calcium influx and inhibits ATP-mediated IL-1βreleasein vitro(KB values are 15 and 92 nM respectively). |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 纯度 | >98 % |
| 计算分子量 | 463.51 |
| 分子式 | C24H21N3O5S |
| 可溶性/溶解性 | Soluble to 10 mM in DMSO |
| CAS号 | 227088-94-0 |
| 参考文献 | Michelet al (2009) Mechanism of action of species-selective P2X(7) receptor antagonists. Br.J.Pharmacol. 156 1312. PMID: 19309360. Stokeset al (2006) Characterization of a selective and potent antagonist of human P2X7 receptors, AZ11645373. Br.J.Pharmacol. 149 880. PMID: 17031385. Alcarazet al (2003) Novel P2X7 receptor antagonists. Bioorg.Med.Chem.Letts. 134043. |