| 货号 | 3937/50 |
| 别名 | 8-Ethoxy-9-ethyl-9H-purin-6-amine |
| 供应商 | Tocris |
| 生物活性 | Adenosine A2A receptor (AA2AR) antagonist (Ki values are 643 and 46 nM for rat and human AA2ARs respectively). Most active AA2AR antagonist for human receptors. Displays activity in the treatment of Parkinson's disease in vivo; improves parkinsonian motor deficits and tremors. Exhibits neuroprotective and anti-inflammatory effects. |
| 运输条件 | Blue Ice |
| 存放说明 | Ambient |
| 纯度 | >99 % |
| 计算分子量 | 207.23 |
| 分子式 | C9H13N5O |
| 可溶性/溶解性 | Soluble to 50 mM in DMSO and to 100 mM in ethanol |
| CAS号 | 634924-89-3 |
| 参考文献 | Pinnaet al (2010) A new ethyladenine antagonist of adenosine A2A receptors: Behavioral and biochemical characterization as an antiparkinsonian drug. Neuropharmacology 58 613. PMID: 19951715. Volpiniet al (2010) Adenosine A2A receptor antagonists: New 8-substituted 9-ethyladenines as tools for in vivo rat models of Parkinson's disease. Chem.Med.Chem. 41010. |