ANA 12 (50 MG)
货号：
4781/50 基本售价：
11381.8 元 规格：
50 mg
产品信息
概述| 货号 | 4781/50 |
| 别名 | N-[2-[[(Hexahydro-2-oxo-1H-azepin-3-yl)amino]carbonyl]phenyl]benzo[b]thiophene-2-carboxamide |
性能| 供应商 | Tocris |
| 生物活性 | TrkB receptor antagonist. Demonstrates a 2-site mode of action, preventing activation by BDNF non-competitively (IC50 values are 45.6 nM and 41.1 μM for the high and low affinity sites respectively). Displays no effect on TrkA and TrkC in an assay of neurite outgrowth. Demonstrates antidepressant properties. |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 纯度 | >99 % |
| 计算分子量 | 407.49 |
| 分子式 | C22H21N3O3 |
| 可溶性/溶解性 | Soluble to 50 mM in DMSO |
| 参考文献 | Cazorlaet al (2011) Identification of a low-molecular weight TrkB antagonist with anxiolytic and antidepressant activity in mice. J.Clin.Invest. 121 1846. PMID: 21505263. |
