| 货号 | 4416/50 |
| 别名 | 2-[(3-Fluorophenyl)ethynyl]-4,6-dim |
| 供应商 | Tocris |
| 生物活性 | Reported to be a negative allosteric modulator at the mGlu5 receptor. Analog of MPEP (Cat. No. 1212). |
| 运输条件 | Blue Ice |
| 存放说明 | Ambient |
| 纯度 | >99 % |
| 计算分子量 | 276.74 |
| 分子式 | C15H13FN2.HCl |
| 可溶性/溶解性 | Soluble to 25 mM in water and to 100 mM in DMSO |
| 参考文献 | Weisset al (2011) 6-Aryl-3-pyrrolidinylpyridines as mGlu5 receptor negative allosteric modulators. Bioorg.Med.Chem.Lett. 21 4891. PMID: 21757343. Marin and Goadsby (2010) Glutamatergic fine tuning with ADX-10059: a novel therapeutic approach for migraine? Expert Opin.Invest.Drugs 19 555. PMID: 20218930. Keywoodet al (2009) A proof-of-concept study evaluating the effect of ADX10059, a metabotropic glutamate receptor-5 negative allosteric modulator, on acid exposure and symptoms in gastro-oesophageal reflux disease. Gut. 58 1192. PMID: 19460767. |