A 887826 (50 MG)
货号：
4249/50 基本售价：
11381.8 元 规格：
50 mg
产品信息
概述| 货号 | 4249/50 |
| 别名 | 5-(4-Butoxy-3-chlorophenyl)-N-[[2-(4-morpholinyl)-3-pyridinyl]methyl-3-pyridine carboxamide |
性能| 供应商 | Tocris |
| 生物活性 | Potent voltage-dependent NaV1.8 channel blocker (IC50 = 11 nM in recombinant human NaV1.8 channels). Reduces tactile allodynia in neuropathic rat models. 3- and 28-fold more potent at NaV1.8 channels compared to NaV1.2 and NaV1.7 channels respectively. |
| 运输条件 | Blue Ice |
| 存放说明 | Ambient |
| 纯度 | >97 % |
| 计算分子量 | 480.99 |
| 分子式 | C26H29ClN4O3 |
| 可溶性/溶解性 | Soluble to 50 mM in DMSO |
| 参考文献 | Zhanget al (2010) A-887826 is a structurally novel, potent and voltage-dependent NaV1.8 sodium channel blocker that attenuates neuropathic tactile allodynia in rats. Neuropharmacology 59 201. PMID: 20566409. |
