| 货号 | 4232/50 |
| 别名 | 1-(2,3-Dichlorophenyl)-N-[[2-(2-pyr |
| 供应商 | Tocris |
| 生物活性 | Potent P2X7 antagonist; blocks BzATP-evoked calcium influx at recombinant human, rat and mouse P2X7 receptors (IC50 values are 20, 42 and 150 nM respectively). Displays antinociceptive effects in rat and mice models of inflammatory pain. CNS penetrant. |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 纯度 | >98 % |
| 计算分子量 | 413.26 |
| 分子式 | C19H14Cl2N6< |
| 可溶性/溶解性 | Soluble to 100 mM in DMSO |
| 参考文献 | Friedleet al (2010) Recent patents on novel P2X7 receptor antagonists and their potential for reducing central nervous system inflammation. Recent Pat.CNS Drug Discov. 5 35. PMID: 19705995. Honoreet al (2009) The antihyperalgesic activity of a selective P2X7 receptor antagonist, A-839977, is lost in IL-1αβ knockout mice. Behav.Brain.Res. 204 77. PMID: 19464323. |