| 货号 | 5740/50 |
| 别名 | 2,5-Dihydroxy-DL-tyrosine |
| 供应商 | Tocris |
| 生物活性 | Allosteric inhibitor of RAD52; inhibits RAD52 binding to single strand DNA binding domains (IC50 = 1.1 μM). Selectively inhibits proliferation of BRCA-deficient cancer cells in vitro. Also inhibits APE1. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 计算分子量 | 213.19 |
| 分子式 | C9H11NO5 |
| 可溶性/溶解性 | Soluble to 100 mM in 1M HCl |
| 参考文献 | Chandramoulyet al (2015) Small-Molecule Disruption of RAD52 Rings as a Mechanism for Precision Medicine in BRCA-Deficient Cancers. Chem.Biol. 22 1491. PMID: 26548611. Wilson DM 3rdet al (2010) Small molecule inhibitors of DNA repair nuclease activities of APE1. Cell Mol.Life Sci. 67 3621. PMID: 20809131. Simeonovet al (2009) Identification and characterization of inhibitors of human apurinic/apyrimidinic endonuclease APE1. PLoS One 4 e5740. PMID: 19484131. |