| 货号 | 1543/50 |
| 别名 | (S)-α-Amino-2,3,4,5,6,7-hexahydro-2, |
| 供应商 | Tocris |
| 生物活性 | Novel subtype-selective and weakly desensitizing AMPA receptor partial agonist (Ki values are 44, 109, 223, 1890 and 2090 nM at GluR5, GluR1, GluR2, GluR3 and GluR4 receptors respectively). Exhibits potent agonist activity at GluR1 and GluR2 subunit-containing AMPA receptors (EC50 values are 24.9 and 13.9 μM respectively) and is excitotoxic in vitro. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 纯度 | >98 % |
| 计算分子量 | 239.23 |
| 分子式 | C10H13N3O4 |
| 可溶性/溶解性 | Soluble to 50 mM in water |
| CAS号 | 389888-02-2 |
| 参考文献 | Butiniet al (2008) 1H-Cyclopentapyrimidine-2,4(1H,3H)-dione-related ionotropic glutamate receptor ligands. Structure-activity relationships and identification of potent and selective iGluR5 modulators. J.Med.Chem. 51 6614. PMID: 18811139. Sinclairet al (2003) Inherent desensitisation-preventing properties of a novel subtype-selective AMPA receptor agonist, (S)-CPW 399, as a possible explanation for its excitotoxic action in cultured cerebellar granule cells. Neurochem.Int. 42 499. PMID: 12547649. Campianiet al (2001) Characterization of the 1H-cyclopentapyrimidine-2,4(1H,3H)-dione derivative (S)-CPW399 as a novel, potent and subtype-selective AMPA receptor full agonist with partial desensitization properties. J.Med.Chem. 44 4501. PMID: 11741469. |