| 货号 | 2148/50 |
| 别名 | (6R,10bS)-rel-1,2,3,5,6,10b-Hexahyd |
| 供应商 | Tocris |
| 生物活性 | Potent, high affinity serotonin re-uptake inhibitor; selective in vivo. Displays moderate selectivity over noradrenalin and dopamine re-uptake in vitro(Ki values are 0.68, 2.9 and 36.8 nM for inhibition of serotonin, noradrenalin and dopamine uptake respectively in rat brain synaptosomes). Potently potentiates 5-HT-induced effects in vivo following oral administration. Biological activity resides predominantly in the (+)-enantiomer. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 纯度 | >98 % |
| 计算分子量 | 295.44 |
| 分子式 | C19H21NS |
| 可溶性/溶解性 | Soluble to 50 mM in 1eq. HCl and to 75 mM in DMSO |
| CAS号 | 96795-89-0 |
| 参考文献 | Smithet al (1991) Effects of pyrroloisoquinoline enantiomers ((+)- and (-)-McN-5652-Z) on behavioral and pharmacological serotonergic mechanisms in rats. Eur.J.Pharmacol. 196 85. PMID: 1831423. Maryanoffet al (1990) Pyrroloisoquinoline antidepressants. 3. A focus on serotonin. J.Med.Chem. 33 2793. PMID: 2213832. Shanket al (1988) McN-5652: a highly potent inhibitor of serotonin uptake. J.Pharmacol.Exp.Ther. 247 1032. PMID: 2905001. |