| 货号 | 2484/50 |
| 别名 | (±)-3-(4-Chlorophenyl)-3-[2-(dimethy |
| 供应商 | Tocris |
| 生物活性 | Highly selective, non-peptide urotensin-II (UT) receptor agonist that displays potent activity at human and rat UT receptors (pEC50 values are 6.5 and 6.7 respectively). |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 纯度 | >98 % |
| 计算分子量 | 366.28 |
| 分子式 | C19H20ClNO2.HCl |
| 可溶性/溶解性 | Soluble to 75 mM in water and to 75 mM in DMSO |
| CAS号 | 477313-09-0 |
| 参考文献 | Lehmannet al (2006) Novel potent and efficacious nonpeptidic urotensin II receptor agonists. J.Med.Chem. 49 2232. PMID: 16570919. Lavecchiaet al (2005) Architecture of the human urotensin II receptor: comparison of the binding domains of peptide and non-peptide urotensin II agonists. J.Med.Chem. 48 2480. PMID: 15801838. Crostonet al (2002) Discovery of the first nonpeptide agonist of the GPR14/urotensin-II receptor: 3-(4-chlorophenyl)-3-(2-(dimethylamino)ethyl)isochroman-1-one (AC-7954). J.Med.Chem. 45 4950. PMID: 12408704. |