| 货号 | 9000326-100mg |
| 描述 | Arachidonyl glycine, the conjugate of arachidonic acid and glycine produced in mammalian brain, skin, and spinal cord, is a structural analog of anandamide (AEA) that is reported to have analgesic activities in whole animal experiments.1,2,3 It has poor affinity for the central cannabinoid (CB1) receptor, high-affinity for the G protein-coupled receptor GPR-18, and is metabolically regulated by fatty acid amide hydrolase (FAAH) activity.4 LinGly is an endogenous homolog of linoleoyl ethanolamide, an arachidonyl glycine. It inhibits the hydrolysis of AEA in FAAH-containing N18TG2 cell membranes with an IC50 value of ~25 µM, which is less potent than that of arachidonyl glycine (IC50 = 7 µM).3 The biological significance of LinGly has not yet been determined. |
| 别名 | Glycine Linoleamide;LinGly;N-Linoleoyl Glycine; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Burstein, S.H.,Rossetti, R.G.,Yagen, B., et al. Oxidative metabolism of anandamide. Prostaglandins & Other Lipid Mediators 61, 29-41 (2000). 2.Huang, S.M.,Bisogno, T.,Petros, T.J., et al. Identification and characterization of an endogenous anandamide-like compound: N-arachidonylglycine (NAGly). ICRS 2001 Symposium on the Cannabinoids 78 (2001). 3.Huang, S.M.,Bisogno, T.,Petros, T.J., et al. Identification of a new class of molecules, the arachidonyl amino acids, and characterization of one member that inhibits pain. The Journal of Biological Chemisty 276(46), 42639-42644 (2001). 4.Rimmerman, N.,Bradshaw, H.B.,Hughes, H.V., et al. N-palmitoyl glycine, a novel endogenous lipid that acts as a modulator of calcium influx and nitric oxide production in sensory neurons. Molecular Pharmacology 74(1), 213-224 (2008). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 337.5 |
| 分子式 | C20H35NO3 |
| CAS号 | 315636 |
| 稳定性 | ≥ 2 years |
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