CAY10681
货号：
15573-25mg 基本售价：
11354.0 元 规格：
25 mg
产品信息
概述| 货号 | 15573-25mg |
| 描述 | Inactivation of the tumor suppressor p53 commonly coincides with increased signaling through NF-κB in cancer. CAY10681 is a dual modulator of p53-MDM2 interaction and NF-κB signaling.1 It potently binds MDM2 (Ki = 250 nM), reducing MDM2-mediated turnover of p53.1 CAY10681 also inhibits phosphorylation of IκBα and dose-dependently reduces nuclear accumulation of p65.1 It blocks the proliferation of cancer cell lines (IC50s range from 33 to 37 µM).1 CAY10681 exhibits excellent oral bioavailability and inhibits tumor growth in A549 xenografts in nude mice.1 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Zhuang, C.,Miao, Z.,Wu, Y., et al. Double-edged swords as cancer therapeutics: Novel, orally active, small molecules simultaneously inhibit p53-MDM2 interaction and the NF-κB pathway. Journal of Medicinal Chemistry 57(3), 567-577 (2014).
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| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 552.5 |
| 分子式 | C30H26BrN5O |
| CAS号 | 1542066-69-2 |
| 稳定性 | ≥ 2 years |
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