| 货号 | 1617/50 |
| 别名 | 3-[(3-Chloro-4-hydroxyphenyl)amino] |
| 供应商 | Tocris |
| 生物活性 | Potent and selective glycogen synthase kinase-3 (GSK-3) inhibitor (Ki = 31 nM for GSK-3α); competes with ATP. Has minimal activity against 24 other protein kinases (IC50 > 10 μ M). Stimulates glycogen synthesis, gene transcription and is neuroprotective. |
| 运输条件 | Blue Ice |
| 存放说明 | Ambient |
| 纯度 | >99 % |
| 计算分子量 | 359.73 |
| 分子式 | C16H10ClN3O5 |
| 可溶性/溶解性 | Soluble to 25 mM in ethanol and to 50 mM in DMSO |
| CAS号 | 264218-23-7 |
| 参考文献 | Liang and Chuang (2006) Regulation and function of glycogen synthase kinase-3 isoforms in neuronal survival. J.Biol.Chem. 282 3904. PMID: 17148450. Crosset al (2001) Selective small-molecule inhibitors of glycogen synthase kinase-3 activity protect primary neurones from death. J.Neurochem. 77 94. PMID: 11279265. Coghlanet al (2000) Selective small molecule inhibitors of glycogen synthase kinase-3 modulate glycogen metabolism and gene transcription. Chem.Biol. 7 793. PMID: 11033082. |