17-phenyl trinor Prostaglandin F2α
货号：
16810-25mg 基本售价：
11270.0 元 规格：
25 mg
产品信息
概述| 货号 | 16810-25mg |
| 描述 | 17-phenyl trinor Prostaglandin F2α (17-phenyl trinor PGF2α) is a metabolically stable analog of PGF2α and is a potent agonist for the FP receptor. It binds to the FP receptor on ovine luteal cells with a relative potency of 756% compared to that of PGF2α.1 At the rat recombinant FP receptor expressed in CHO cells bimatoprost inhibits PGF2α binding with a Ki of 1.1 nM.2 The isopropyl ester of 17-phenyl trinor PGF2α ethyl amide is slightly better than PGF2α isopropyl ester in reducing the intraocular pressure in the cat eye without any irritation.3 |
| 别名 | Bimatoprost (free acid);17-phenyl trinor PGF2α; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Balapure, A.K.,Rexroad, C.E., Jr.,Kawada, K., et al. Structural requirements for prostaglandin analog interaction with the ovine corpus luteum prostaglandin F2α receptor. Biochemical Pharmacology 38, 2375-2381 (1989).
2.Lake, S.,Gullberg, H.,Wahlqvist, J., et al. Cloning of the rat and human prostaglandin F2α receptors and the expression of the rat prostaglandin F2α receptor. FEBS Letters 355, 317-325 (1994).
3.Stjernschantz, J., and Resul, B. Phenyl substituted prostaglandin analogs for glaucoma treatment. Drugs of the Future 17, 691-704 (1992).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 388.5 |
| 分子式 | C23H32O5 |
| CAS号 | 38344-08-0 |
| 稳定性 | ≥ 2 years |
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