| 货号 | 10011718-50mg |
| 描述 | 1-Deoxynojirimycin (1-dNM) (hydrochloride), produced by Bacillus species, is a glucose analog that potently inhibits α-glucosidase I and II. It prevents the formation of complex N-linked oligosaccharides in yeast and intact mammalian cells by inhibiting both α-glucosidase I and II with IC50 values of ~2 µM.1,2 The FDA has granted orphan drug designation to dNM (hydrochloride) for the treatment of Pompe disease, an inherited lysosomal storage disorder caused by a mutation that alters the structure and stability of α-glucosidase. 1-dNM, at a concentration of 0.4 mM, also inhibits virus spread in HIV-infected lymphocyte cultures by interfering with α-glucosidase activity.3,4 |
| 别名 | 1-dNM;Moranoline; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Suanier, B.,Kilker, R.D., Jr.,Tkacz, J.S., et al. Inhibition of N-linked complex oligosaccharide formation by 1-deoxynojirimycin, an inhibitor of processing glucosidases. The Journal of Biological Chemisty 257(23), 14155-14161 (1982). 2.Suh, K.,Gabel, C.A. and Bergmann, J.E. Identification of a novel mechanism for the removal of glucose residues from high mannose-type oligosaccharides. The Journal of Biological Chemisty 267(30), 21671-21677 (1992). 3.Montefiori, D.C.,Robinson, W.E., Jr. and Mitchell, W.M. Role of protein N-glycosylation in pathogenesis of human immunodeficiency virus type 1. Proceedings of the National Academy of Sciences of the United States of America 85, 9248-9252 (1988). 4.Papandréou, M.J.,Barbouche, R.,Guieu, R., et al. The α-glucosidase inhibitor 1-deoxynojirimycin blocks human immunodeficiency virus envelope glycoprotein-mediated membrane fusion at the CXCR4 binding step. Molecular Pharmacology 61, 186-193 (2002). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 199.6 |
| 分子式 | C6H13NO4 • HCl |
| CAS号 | 73285-50-4 |
| 稳定性 | ≥ 2 years |
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