N-3-oxo-dodecanoyl-L-Homoserine lactone
货号：
10007895-50mg 基本售价：
11270.0 元 规格：
50 mg
产品信息
概述| 货号 | 10007895-50mg |
| 描述 | Quorum sensing is a regulatory system used by bacteria for controlling gene expression in response to increasing cell density.1 A promising field of study involves controlling bacterial infections by quenching their quorum sensing systems. The expression of specific target genes, such as transcriptional regulators belonging to the LuxIR family of proteins, is coordinated by synthesis of diffusible acylhomoserine lactone (AHL) molecules.1 N-3-oxo-dodecanoyl-L-homoserine lactone (3-oxo-C12-HSL) is one of the AHLs frequently identified in extracts of respiratory secretions from cystic fibrosis patients infected with P. aeruginosa and/or strains of the B. cepaciacomplex.2 3-oxo-C12-HSL activates the transcription factors NF-κB and AP-2 to induce interleukin-8 production in human lung fibroblasts and epithelial cells, possibly contributing to the neutrophil infiltration and inflammation found in P. aeruginosainfections.3 |
| 别名 | 3-oxo-C12-HSL; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Henke, J.M., and Bassler, B.L. Bacterial social engagements. Trends in Cell Biology 14(11), 648-656 (2004).
2.Chambers, C.E.,Visser, M.B.,Schwab, U., et al. Identification of N-acylhomoserine lactones in mucopurulent respiratory secretions from cystic fibrosis patients. FEMS Microbiology Letters 244, 297-304 (2005).
3.Smith, R.S.,Fedyk, E.R.,Springer, T.A., et al. IL-8 production in human lung fibroblasts and epithelial cells activated by the Pseudomonas autoinducer N-3-oxododecanoyl homoserine lactone is transcriptionally regulated by NF-κB and activator protein-2. Journal of Immunology 167, 366-374 (2001).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 297.4 |
| 分子式 | C16H27NO4 |
| CAS号 | 168982-69-2 |
| 稳定性 | ≥ 1 year |
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