RMM 46 ( )
货号：
5909/50 基本售价：
11233.1 元 规格：
50 mg
产品信息
概述| 货号 | 5909/50 |
| 别名 | 2-Cyano-N-(2-hydroxy-1,1-dimethylethyl)-3-[3-(3,4,5-trimethoxyphenyl)-1H-indazol-5-yl]-2-propenamide |
性能| 供应商 | Tocris |
| 生物活性 | MSK/RSK family kinase inhibitor. Exhibits selectivity for RSK2 over NEK2 and PLK1 (IC50s are 12, 530 and 2200 nM, respectively). Inhibits MSK1, MSK2, RSK2 and RSK3 in cellular assays. Reduces CREB phosphorylation in HeLa cells. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 纯度 | >98 % |
| 计算分子量 | 450.5 |
| 分子式 | C24H26N4O5 |
| 可溶性/溶解性 | Soluble to 100 mM in DMSO |
| 参考文献 | Milleret al (2013) Electrophilic fragment-based design of reversible covalent kinase inhibitors. J.Am.Chem.Soc. 135 5298. PMID: 23540679. |
