| 货号 | 5757/50 |
| 别名 | N-[2-[[[4-[2-(3,4-dihydro-6,7-dimet |
| 供应商 | Tocris |
| 生物活性 | Potent P-glycoprotein (P-gp) inhibitor (IC50 = 5.1 nM). Reverses drug resistance in multiple MDR cell lines. Acts as a substrate for breast cancer resistance protein (BCRP) at low concentrations and acts as an inhibitor of BCRP when used at >100 nM concentration. Potentiates the cytotoxic effects of doxorubicin (Cat. No. 2252) and mitoxantrone (Cat. No. 4250) in vitro. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 纯度 | >98 % |
| 计算分子量 | 719.66 |
| 分子式 | C38H38N4O6 |
| 可溶性/溶解性 | Soluble to 100 mM in DMSO |
| 参考文献 | Looet al (2015) Mapping the binding site of the inhibitor Tariquidar that stabilizes the first transmembrane domain of P-glycoprotein. J.Biol.Chem. 290 29389. PMID: 26507655. Kannanet al (2011) The "specific" P-glycoprotein inhibitor Tariquidar is also a substrate and an inhibitor for breast cancer resistance protein (BCRP/ABCG2). ACS Chem.Neurosci. 2 82. PMID: 22778859. |