| 货号 | 5456/50 |
| 别名 | (αR)-4-[(1aα,6α,10bα)-1,1-Difluoro-1,1a |
| 供应商 | Tocris |
| 生物活性 | High affinity P-glycoprotein (P-gp) inhibitor (Kd = 79 nM). Restores doxorubicin (Cat. No. 2252) sensitivity in P-gp-expressing multidrug (MDR) resistant cancer cell lines. Also potentiates antitumor efficacy of taxol (Cat. No. 1097) in a MDR human non-small cell lung carcinoma xenograft mouse model. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 纯度 | >98 % |
| 计算分子量 | 636.99 |
| 分子式 | C32H31F2N3 |
| 可溶性/溶解性 | Soluble to 50 mM in DMSO |
| 参考文献 | Dantziget al (1999) Selectivity of the multidrug resistance modulator, LY335979, for P-glycoprotein and effect on cytochrome P-450 activities. J.Pharmacol.Exp.Ther. 290 854. PMID: 10411602. Dantziget al (1996) Reversal of P-glycoprotein-mediated multidrug resistance by a potent cyclopropyldibenzosuberane modulator, LY335979. Cancer Res. 56 4171. PMID: 8797588. |