| 货号 | 2076/50 |
| 别名 | N-[(3S,4R)-6-Cyano-3,4-dihydro-3-hy |
| 供应商 | Tocris |
| 生物活性 | Kir6 (KATP) channel opener and active metabolite of Y-27152 (Cat. No. 2077). Relaxes contracted rat aortic rings (IC50 = 0.027 mM) and inhibits glucose-induced insulin secretion in isolated human pancreatic β-cellsin vitro. Produces hypotension in spontaneously hypertensive rats and displays cardioprotective properties in dogs following systemic administration in vivo. |
| 运输条件 | Blue Ice |
| 存放说明 | Ambient |
| 纯度 | >98 % |
| 计算分子量 | 276.29 |
| 分子式 | C14H16N2O4 |
| 可溶性/溶解性 | Soluble to 100 mM in 1eq. NaOH |
| CAS号 | 127408-31-5 |
| 参考文献 | Cosgroveet al (2004) Y-26763: ATP-sensitive K+ channel activation and the inhibition of insulin release from human pancreatic β-cells Eur.J.Pharmacol. 486 133. PMID: 14975702. Fukunariet al (1997) Y-26763 protects the canine heart from a stunning injury through opening of the KATP channels Eur.J.Pharmacol. 323 197. PMID: 9128839. Nakajimaet al (1992) Y-27152, a long-acting K+ channel opener with less tachycardia: antihypertensive effects in hypertensive rats and dogs in conscious state. J.Pharmacol.Exp.Ther. 261 730. PMID: 1578381. |