XAP 044 (50 MG)
货号：
5248/50 基本售价：
11233.1 元 规格：
50 mg
产品信息
概述| 货号 | 5248/50 |
| 别名 | 7-Hydroxy-3-(4-iodophenoxy)-4H-1-benzopyran-4-one |
性能| 供应商 | Tocris |
| 生物活性 | Potent and selective mGlu7 antagonist (IC50 = 88 nM); inhibits lateral amygdala long term potentiation (LTP) in brain slices from wild type mice. Displays no effects on the LTP of mGlu7 deficient mice. Exhibits novel activity by binding to the mGlu7 Venus flytrap domain (VFTD). Exhibits anti-anxiety effects in rodent models. Brain penetrant. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 纯度 | >98 % |
| 计算分子量 | 380.13 |
| 分子式 | C15H9IO4 |
| 可溶性/溶解性 | Soluble to 100 mM in DMSO and to 20 mM in ethanol |
| 参考文献 | Geeet al (2014) Blocking metabotropic glutamate receptor subtype 7 (mGlu7) via the Venus flytrap domain (VFTD) inhibits amygdala plasticity, stress, and anxiety-related behavior. J.Biol.Chem. 289 10975. PMID: 24596089. |
