VU 0469650 hydrochloride (50 MG)
货号：
5379/50 基本售价：
11233.1 元 规格：
50 mg
产品信息
概述| 货号 | 5379/50 |
| 别名 | 3-[(3R)-3-Methyl-4-(tricyclo[3.3.1.13,7]dec-1-ylcarbonyl)-1-piperazinyl]-2-pyridinecarbonitrile hydrochloride |
性能| 供应商 | Tocris |
| 生物活性 | Potent and selective negative allosteric modulator of mGlu1(IC50 = 99 nM). Exhibits >100-fold selectivity for mGlu1 over mGlu2-8 and 68 other GPCRs, ion channels, kinases and transporters. Brain penetrant. |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 纯度 | >98 % |
| 计算分子量 | 400.94 |
| 分子式 | C22H28N4O.HCl |
| 可溶性/溶解性 | Soluble to 100 mM in DMSO and to 50 mM in ethanol |
| 参考文献 | Lovellet al(2013)N-Acyl-N-arylpiperazines as negative allosteric modulators of mGlu1: Identification of VU0469650, a potent and selective tool compound with CNS exposure in rats. Bioorg.Med.Chem.Lett. 23 3713. PMID: 23727046. |
