VU 0422288 (50 MG)
货号：
5378/50 基本售价：
11233.1 元 规格：
50 mg
产品信息
概述| 货号 | 5378/50 |
| 别名 | N-[3-Chloro-4-[(5-chloro-2-pyridinyl)oxy]phenyl]-2-pyridinecarboxamide; ML 396 |
性能| 供应商 | Tocris |
| 生物活性 | Group III mGlu receptor positive allosteric modulator (EC50 values are 108, 125 and 146 nM for mGlu4, mGlu8 and mGlu7 respectively). Exhibits selectivity over a panel of 68 other GPCRs, ion channels and transporters. Potentiates mGlu7-mediated reductions in excitatory post synaptic potentials in hippocampal slices. |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 纯度 | >98 % |
| 计算分子量 | 360.19 |
| 分子式 | C17H11Cl2N3< |
| 可溶性/溶解性 | Soluble to 100 mM in DMSO |
| 参考文献 | Jalan-Sakrikaret al (2014) Identification of positive allosteric modulators VU0155094 (ML397) and VU0422288 (ML396) reveals new insights into the biology of metabotropic glutamate receptor 7. ACS Chem.Neurosci. 5 1221. PMID: 25225882. |
