| 货号 | 5269/50 |
| 别名 | 3-Methyl-N-[3-[[[3-(trifluoromethyl |
| 供应商 | Tocris |
| 生物活性 | Selective LIM kinase 2 (LIMK2) inhibitor; inhibits cofilin phosphorylation in cells that overexpress LIMK2 but not LIMK1. Attenuates the growth of several cancer cell lines. Reduces phospho-cofilin levels and Panc-1 tumor size in a mouse xenograft model. |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 纯度 | >99 % |
| 计算分子量 | 389.33 |
| 分子式 | C19H14F3N3 |
| 可溶性/溶解性 | Soluble to 50 mM in DMSO |
| 参考文献 | Raket al (2014) Novel LIMK2 inhibitor blocks Panc-1 tumor growth in a mouse xenograft model. Oncoscience 1 39. PMID: 25593987. Mashiach-Farkashet al (2012) Computer-based identification of a novel LIMK1/2 inhibitor that synergizes with salirasib to destabilize the actin cytoskeleton. Oncotarget 3 629. PMID: 22776759. |