| 货号 | 3986/50 |
| 别名 | [[(7S)-7-[[(2R)-2-(3-chlorophenyl)- |
| 供应商 | Tocris |
| 生物活性 | Selectiveβ3-adrenergic receptor agonist. Displays both anxiolytic and antidepressant effects in rodent models. Orally active and brain penetrant. |
| 运输条件 | Blue Ice |
| 存放说明 | Ambient |
| 纯度 | >98 % |
| 计算分子量 | 440.36 |
| 分子式 | C22H26ClNO4.HCl |
| 可溶性/溶解性 | Soluble to 100 mM in DMSO |
| 参考文献 | Tamburellaet al (2010) The beta(3) adrenoceptor agonist, amibegron (SR58611A) counteracts stress-induced behavioral and neurochemical changes. Eur.Neuropsychopharmacol. 20 704. PMID: 20537869. Claustreet al (2008) Effects of the β3-adrenoceptor (Adrb3) agonist SR58611A (amibegron) on serotonergic and noradrenergic transmission in the rodent: relevance to its antidepressant/anxiolytic-like profile. Neuroscience 156 353. PMID: 18691638. Stemmelinet al (2008) Stimulation of the β3-adrenoceptor as a novel treatment strategy for anxiety and depressive disorders. Neuropsychopharmacology 33 574. PMID: 17460614. Consoliet al (2007) Behavioral effects of the β3 adrenoceptor agonist SR58611A: is it the putative prototype of a new class of antidepressant/anxiolytic drugs? Eur.J.Pharmacol 573 139. PMID: 17669397. |