| 货号 | 4868/50 |
| 别名 | N-[4-Methyl-5-[[[4-[2,2,2-trifluoro |
| 供应商 | Tocris |
| 生物活性 | Retinoic acid receptor-related orphan receptor (ROR) αandγ inverse agonist (Ki values are 172 and 111 nM for RORα and RORγ respectively). Demonstrates no activity at RORβ or LXR. Suppresses Th17 cell differentiation and cytokine expression and reduces the severity of disease in an animal model of mulitple sclerosis. |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 纯度 | >98 % |
| 计算分子量 | 477.4 |
| 分子式 | C15H13F6N3 |
| 可溶性/溶解性 | Soluble to 100 mM in DMSO and to 100 mM in ethanol |
| 参考文献 | Beurelet al (2013) Inflammatory T helper 17 cells promote depression-like behavior in mice. Biol.Psychiatry 73 622. PMID: 23174342. Crumbleyet al (2012) Regulation of expression of citrate synthase by the retinoic acid receptor-related orphan receptor α(RORα). PLoS ONE 7 33804. PMID: 22485150. Soltet al (2011) Suppression of TH17 differentiation and autoimmunity by a synthetic ROR ligand. Nature 472 491. PMID: 21499262. |