| 货号 | 1690/50 |
| 别名 | 2-Methyl-8-(phenylmethoxy)imidazo[1 |
| 供应商 | Tocris |
| 生物活性 | Potent inhibitor of H+,K+-ATPase (IC50 = 20 nM); binds to the K+ recognition site and is competitive with respect to K+. Inhibits gastric acid secretion in vitroandin vivo. |
| 运输条件 | Blue Ice |
| 存放说明 | Ambient |
| 纯度 | >99 % |
| 计算分子量 | 277.33 |
| 分子式 | C17H15N3O |
| 可溶性/溶解性 | Soluble to 10 mM in ethanol and to 25 mM in DMSO |
| CAS号 | 76081-98-6 |
| 参考文献 | Vaginet al (2002) SCH 28080, a K+-competitive inhibitor of the gastric H,K-ATPase, binds near the M5-6 luminal loop, preventing K+ access to the ion binding domain. Biochemistry 41 12755. PMID: 12379118. Scottet al (1987) Studies on the mechanism of action of the gastric microsomal (H+K+)-ATPase inhibitors SCH 32651 and SCH 28080. Biochem.Pharmacol. 36 97. PMID: 3026407. Longet al (1983) Gastric antisecretory and cytoprotective activities of SCH 28080. J.Pharmacol.Exp.Ther. 226 114. PMID: 6864535. |