| 货号 | 3617/50 |
| 别名 | N-[3-(1H-Benzimidazol-2-yl)-4-chlor |
| 供应商 | Tocris |
| 生物活性 | Inhibitor of Sonic hedgehog (Shh) signaling; antagonizes smoothened receptor activity (KD = 12 nM). Displays allosteric binding characteristics similar to SANT-1 (Cat. No. 1974). Displaces smo-[3H]SAG-1.3 and -[3H]Cyclopamine binding (Ki values are 7.8 nM and 8.4 nM respectively). |
| 运输条件 | Blue Ice |
| 存放说明 | Ambient |
| 纯度 | >98 % |
| 计算分子量 | 479.96 |
| 分子式 | C25H25ClN3O4 |
| 可溶性/溶解性 | Soluble to 100 mM in DMSO and to 100 mM in ethanol |
| CAS号 | 329196-48-7 |
| 参考文献 | Romingeret al (2009) Evidence for allosteric interactions of antagonist binding to the smoothened receptor. J.Pharmacol.Exp.Ther. 329 995. PMID: 19304771. Chenet al (2002) Small molecule modulation of smoothened activity. Proc.Natl.Acad.Sci. 9914071. |