| 货号 | 2609/50 |
| 别名 | 2-Methyl-5-[(4-methylphenyl)amino]- |
| 供应商 | Tocris |
| 生物活性 | Inhibitor of SETD8 protein lysine methyltransferase (PKMT) (IC50 = 0.5 μM); suppresses H4K20 monomethylation in vitro. Also inhibits cyclin-dependent kinase (CDK) 4 (IC50 = 6.0 μM at CDK4/cyclin D1). Induces S phase accumulation in HEK293T cells. Cytotoxic against a range of human cancer cells. |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 纯度 | >98 % |
| 计算分子量 | 284.33 |
| 分子式 | C15H12N2O2S |
| 可溶性/溶解性 | Soluble to 20 mM in DMSO and to 5 mM in ethanol |
| CAS号 | 265312-55-8 |
| 参考文献 | Blumet al (2014) Small-molecule inhibitors of SETD8 with cellular activity. ASC.Chem.Biol. [Epub ahead of print] 9 2471. PMID: 25137013. Ryuet al (2000) 5-Arylamino-2-methyl-4,7-dioxobenzothiazoles as inhibitors of cyclin-dependent kinase 4 and cytotoxic agents. Bioorg.Med.Chem.Lett. 10 461. PMID: 10743948. |