| 货号 | 2272/50 |
| 别名 | 2,3,4,10-Tetrahydro-7,10-dimethyl-2 |
| 供应商 | Tocris |
| 生物活性 | Non-peptide inhibitor of NGF that binds the NGF dimer (KD ~ 1 μM) possibly causing a conformational change. Selectively inhibits binding of NGF to p75NTR at submicromolar concentrations, and to both p75NTR and TrkA at concentrations > 5 μM. Prevents NGF-induced apoptosis in SK-N-MC cells. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 纯度 | >95 % |
| 计算分子量 | 270.24 |
| 分子式 | C13H10N4O3 |
| 可溶性/溶解性 | Soluble to 50 mM in 1eq. NaOH and to 10 mM in DMSO with gentle warming |
| CAS号 | 37854-59-4 |
| 参考文献 | Arkin and Wells (2004) Small-molecule inhibitors of protein-protein interactions: progressing towards the dream. Nat.Rev.Drug Discov. 3 301. PMID: 15060526. Niederhauseret al (2000) NGF ligand alters NGF signaling via p75NTR and TrkA. J.Neurosci.Res. 61 263. PMID: 10900073. |