| 货号 | 5470/50 |
| 别名 | 2,2'-[1,2-Diazenediylbis(4,1-phenyle |
| 供应商 | Tocris |
| 生物活性 | Photoswitchable Nav, Cav and Kv channel blocker. Blocks channels in the trans conformation. Switches conformation from cistotrans at 500 nm and transtocis at 380 nm. Normally membrane impermeant, but enters nociceptive neurons via ion channels activated by noxious stimuli, particularly TRPV1. Exhibits optically reversible local anesthesia in rats. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 纯度 | >98 % |
| 计算分子量 | 567.59 |
| 分子式 | C28H44Cl2N6< |
| 可溶性/溶解性 | Soluble to 50 mM in water |
| 参考文献 | Mourotet al (2012) Rapid optical control of nociception with an ion-channel photoswitch. Nat.Methods 9 396. PMID: 22343342. Banghart MRet al (2009) Photochromic blockers of voltage-gated potassium channels. Angew.Chem.Int.Ed. 48 9097. PMID: 19882609. |