| 货号 | 5321/50 |
| 别名 | N-(4-Chlorophenyl)-N'-[3-[6-(1-pyrro |
| 供应商 | Tocris |
| 生物活性 | CB1 receptor negative allosteric modulator (IC50 values are 45 and 209 nM for the inhibition of CP 55,940 and WIN 55,212-2 respectively). Has no effect at the CB2 receptor. Decreases food intake and body weight in rats. |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 纯度 | >99 % |
| 计算分子量 | 392.88 |
| 分子式 | C22H21ClN4O |
| 可溶性/溶解性 | Soluble to 100 mM in DMSO |
| 参考文献 | Germanet al (2014) Diarylureas as allosteric modulators of the cannabinoid CB1 receptor: structure-activity relationship studies on 1-(4-chlorophenyl)-3-{3-[6-(pyrrolidin-1-yl)pyridin-2-yl]phenyl}urea (PSNCBAM-1). J.Med.Chem. 57 7758. PMID: 25162172. Horswillet al (2007) PSNCBAM-1, a novel allosteric antagonist at cannabinoid CB1 receptors with hypophagic effects in rats. Br.J.Pharmacol. 152 805. PMID: 17592509. |