| 货号 | 4445/50 |
| 别名 | 2-Methoxy-N-(3-methyl-2-oxo-1,2,3,4 |
| 供应商 | Tocris |
| 生物活性 | Potent BET bromodomain inhibitor; exhibits inhibitory activity at bromodomain-containing protein (BRD) 2 and BRD4 (IC50 values are 98 and 220 nM respectively). Induces apoptosis and G1 cell cycle arrest in BET inhibitor-sensitive cell lines (MV4;11). Also downregulates Aurora B expression in MV4;11 cells. Cell permeable. |
| 运输条件 | Blue Ice |
| 存放说明 | Ambient |
| 纯度 | >98 % |
| 计算分子量 | 347.39 |
| 分子式 | C16H17N3O4 |
| 可溶性/溶解性 | Soluble to 50 mM in DMSO |
| 参考文献 | Picaudet al (2013) PFI-1 - a highly selective protein interaction inhibitor targeting BET bromodomains. Cancer Res. [Epub ahead of print]. Fishet al (2012) Identification of a chemical probe for bromo and extra c-terminal bromodomain inhibition through optimization of a fragment-derived hit. J.Med.Chem. [Epub ahead of print]. PMID: 23095041. |