| 货号 | 4788/50 |
| 别名 | N'-[3,5-Bis(trifluoromethyl)phenyl]- |
| 供应商 | Tocris |
| 生物活性 | Activator of large-conductance Ca2+-activated potassium channels (BKCa, KCa1.1). Exhibits no modulatory effect on a variety of K+(KV), Na+ and Ca2+ currents at concentrations <10 μM. Alters gating kinetics, but does not affect single channel conductance. Shown to bind BKCa in open and closed conformations; thought to bind the αsubunit. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 纯度 | >98 % |
| 计算分子量 | 511.24 |
| 分子式 | C16H9BrF6N6< |
| 可溶性/溶解性 | Soluble to 100 mM in ethanol and to 100 mM in DMSO |
| 参考文献 | Kunet al (2009) NS11021, a novel opener of large-conductance Ca2+-activated K+ channels, enhances erectile responses in rats. Br.J.Pharmacol. 158 1465. PMID: 19845682. Layneet al (2009) BK channel activation by NS11021 decreases excitability and contractility of urinary bladder smooth muscle. Am.J.Physiol.Regul.Integr.Comp.Physiol. 298 R378. PMID: 19923353. Bentzenet al (2007) The small molecule NS11021 is a potent and specific activator of Ca2+-activated big-conductance K+ channels. Mol.Pharmacol. 72 1033. PMID: 17636045. |