| 货号 | 1746/50 |
| 别名 | cis-5-Chloro-2-methoxy-4-(methylami |
| 供应商 | Tocris |
| 生物活性 | Highly potent dopamine D2-like receptor antagonist; selective over D1-like receptors (Ki values are 0.1 and 740 nM for D2-like and D1-like receptors respectively). Also potent 5-HT1A receptor agonist (IC50 = 34 nM) and has affinity for sigma receptors. |
| 运输条件 | Blue Ice |
| 存放说明 | Ambient |
| 纯度 | >99 % |
| 计算分子量 | 387.91 |
| 分子式 | C21H26ClN3O2 |
| 可溶性/溶解性 | Soluble to 20 mM in ethanol and to 25 mM in DMSO |
| CAS号 | 75272-39-8 |
| 参考文献 | Assieet al (1997) 5-HT1A receptor agonist properties of the antipsychotic, nemonapride: comparison with bromerguride and clozapine. Eur.J.Pharmacol. 334 141. PMID: 9369342. Ujikeet al (1996) [3H]YM-09151-2 (nemonapride), a potent radioligand for both sigma1 and sigma2 receptor subtypes. Neuroreport 7 1057. PMID: 8804051. Teraiet al (1983) Selective binding of YM-09151-2, a new potent neuroleptic, to D2-dopaminergic receptors. Jpn.J.Pharmacol. 33 749. PMID: 6138453. |