| 货号 | 5131/50 |
| 别名 | N-[(2-Chlorophenyl)methyl]-1-(2,5-d |
| 供应商 | Tocris |
| 生物活性 | Protects against α-synuclein toxicity. Reverses the α-synuclein-induced pathological phenotype in Parkinson's disease cortical neurons. Promotes E3 ubiquitin ligase Rsp5/Nedd4-dependent endosomal transport. |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 纯度 | >98 % |
| 计算分子量 | 389.88 |
| 分子式 | C23H20ClN3O |
| 可溶性/溶解性 | Soluble to 100 mM in DMSO and to 100 mM in ethanol |
| 参考文献 | Chunget al (2013) Identification and rescue of α-synuclein toxicity in Parkinson patient-derived neurons. Science 342 983. PMID: 24158904. Tardiffet al (2013) Yeast reveal a "druggable" Rsp5/Nedd4 network that ameliorates α-synuclein toxicity in neurons. Science 342 979. PMID: 24158909. |