| 货号 | 5246/50 |
| 别名 | 4-Ethyl-1,4-dihydro-5-[[(2-methoxye |
| 供应商 | Tocris |
| 生物活性 | TRPV1 positive allosteric modulator. Potentiates vanilloid and proton activation of TRPV1 channels. Exhibits analgesic effects in combination with capsaicin (Cat. No. 0462) in rats. Also prolongs capsaicin-induced hypothermia in mice. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 纯度 | >98 % |
| 计算分子量 | 389.51 |
| 分子式 | C21H27NO4S |
| 可溶性/溶解性 | Soluble to 100 mM in DMSO and to 50 mM in ethanol |
| 参考文献 | Kaszaset al (2012) Small molecule positive allosteric modulation of TRPV1 activation by vanilloids and acidic pH. J.Pharmacol.Exp.Ther. 340 152. PMID: 22005042. Lebovitzet al (2012) Positive allosteric modulation of TRPV1 as a novel analgesic mechanism. Mol.Pain 8. PMID: 22998799. Rohet al (2008) Structure-activity relationships of 1,4-dihydropyridines that act as enhancers of the vanilloid receptor 1 (TRPV1). Bioorg.Med.Chem. 16 9349. PMID: 18809334. |