ML 337 (50 MG)
货号：
4982/50 基本售价：
11233.1 元 规格：
50 mg
产品信息
概述| 货号 | 4982/50 |
| 别名 | [2-Fluoro-4-[2-(4-methoxyphenyl)ethynyl]phenyl][(3R)-3-hydroxy-1-piperidinyl]methanone |
性能| 供应商 | Tocris |
| 生物活性 | Selective negative allosteric modulator of mGlu3(IC50 = 593 nM). Displays no activity at mGlu1, mGlu2 or mGlu4-8 at concentrations up to 30 μM. Brain penetrant. |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 纯度 | >98 % |
| 计算分子量 | 353.39 |
| 分子式 | C21H20FNO3 |
| 可溶性/溶解性 | Soluble to 100 mM in DMSO and to 20 mM in ethanol |
| 参考文献 | Wenthuret al (2013) Discovery of (R)-(2-fluoro-4-((-4-methoxyphenyl)ethynyl)phenyl) (3-hydroxypiperidin-1-yl)methanone (ML337), an mGlu3 selective and CNS penetrant negative allosteric modulator (NAM). J.Med.Chem. 56 5208. PMID: 23718281. |
