ML 240 (50 MG)
货号：
5153/50 基本售价：
11233.1 元 规格：
50 mg
产品信息
概述| 货号 | 5153/50 |
| 别名 | 2-(2-Amino-1H-benzimidazole-1-yl)-8-methoxy-N-(phenylmethyl)-4-quinazolinamine |
性能| 供应商 | Tocris |
| 生物活性 | ATP-competitive inhibitor of p97 ATPase (IC50 = 110 nM). Exhibits antiproliferative activity in NCI-60 cancer cell lines and rapidly induces executioner caspases 3 and 7 in multiple colon cancer cells. Promotes accumulation of LC3-II and impairs autophagosome maturation. Also impairs the endoplasmic-reticulum-associated degradation (ERAD) pathway. |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 纯度 | >99 % |
| 计算分子量 | 396.44 |
| 分子式 | C23H20N6O |
| 可溶性/溶解性 | Soluble to 20 mM in DMSO |
| 参考文献 | Chouet al (2013) Structure-activity relationship study reveals ML240 and ML241 as potent and selective inhibitors of p97 ATPase. ChemMedChem 8 297. PMID: 23316025. |
