| 货号 | 1521/50 |
| 别名 | (2R*,4S*)-4-(1H-Tetrazol-5-ylmethyl |
| 供应商 | Tocris |
| 生物活性 | Competitive NMDA receptor antagonist (IC50 = 7 nM) that displays no affinity for AMPA or kainate receptors at a concentration of 10 μM. Inhibits NMDA-induced neuronal degeneration and protects from NMDA-induced convulsions in neonatal rats. |
| 运输条件 | Blue Ice |
| 存放说明 | Ambient |
| 纯度 | >99 % |
| 计算分子量 | 211.22 |
| 分子式 | C8H13N5O2 |
| 可溶性/溶解性 | Soluble to 100 mM in water and to 100 mM in DMSO |
| CAS号 | 125546-04-5 |
| 参考文献 | Maddenet al (1993) Delayed therapy of experimental ischemia with competitive N-methyl-D-aspartate antagonists in rabbits. Stroke 24 1068. PMID: 8322381. Maddenet al (1992) Efficacy of LY233053, a competitive glutamate antagonist, in experimental central nervous system ischemia. J.Neurosurg. 76 106. PMID: 1727148. Schoeppet al (1990) Pharmacological characterization of LY233053: a structurally novel tetrazole-substituted competitive N-methyl-D-aspartic acid antagonist with a short duration of action. J.Pharmacol.Exp.Ther. 255 1301. PMID: 2148188. |