| 货号 | 5214/50 |
| 别名 | N-(6-Methyl-2-benzothiazolyl)-2-[(3 |
| 供应商 | Tocris |
| 生物活性 | Potent inhibitor of Wnt/β-catenin signaling (IC50 = 25 nM). Has minimal effect on Notch and Hedgehog signaling pathways. Induces differentiation of cardiomyocytes from human ESCs and iPSCs. |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 纯度 | >98 % |
| 计算分子量 | 496.62 |
| 分子式 | C23H20N4O3 |
| 可溶性/溶解性 | Soluble to 10 mM in DMSO with sonication |
| 参考文献 | Narytnyket al (2014) Differentiation of human epidermal neural crest stem cells (hEPI-NCSC) into virtually homogenous populations of dopaminergic neurons. Stem Cell Rev. 10 316. PMID: 24399192. Lianet al (2012) Robust cardiomyocyte differentiation from human pluripotent stem cells via temporal modulation of canonical Wnt signaling. Proc.Natl.Acad.Sci.U.S.A. 109 E1848-57. PMID: 22645348. Chenet al (2009) Small molecule-mediated disruption of Wnt-dependent signaling in tissue regeneration and cancer. Nat.Chem.Biol. 5 100. PMID: 19125156. |