| 货号 | 5774/50 |
| 别名 | N-[2,3-Dihydro-3-[(5-methoxy-1H-ind |
| 供应商 | Tocris |
| 生物活性 | ERK dimerization inhibitor (IC50 ~ 0.5 μM); inhibits ERK dimerization without affecting phosphorylation or kinase activity. Suppresses growth of tumor cells expressing RAS-ERK oncogenes in vitro. Induces apoptosis and prevents tumor progression in vivo. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 纯度 | >98 % |
| 计算分子量 | 444.53 |
| 分子式 | C26H28N4O3 |
| 可溶性/溶解性 | Soluble to 50 mM in DMSO |
| 参考文献 | Herreroet al (2015) Small molecule inhibition of ERK dimerization prevents tumorigenesis by RAS-ERK pathway oncogenes. Cancer Cell 28 170. PMID: 26267534. Ryanet al (2015) Targeting RAS-mutant cancers: is ERK the key? Trends Cancer 1 183. PMID: 26858988. |