| 货号 | 5414/50 |
| 别名 | N-Methyl-4-nitro-2-(4-(4-trifluorom |
| 供应商 | Tocris |
| 生物活性 | Potent TLR1/2 agonist (EC50 = 52.9 nM). Activates the NF-κB pathway and upregulates proinflammatory cytokines in vitro. Also enhances TLR1 and TLR2 dimerization. |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 纯度 | >99 % |
| 计算分子量 | 362.31 |
| 分子式 | C17H13F3N4 |
| 可溶性/溶解性 | Soluble to 100 mM in DMSO and to 20 mM in ethanol |
| 参考文献 | Chenget al (2015) Specific activation of the TLR1-TLR2 heterodimer by small-molecule agonists Sci.Adv. 1 e1400139. PMID: 26101787. Chenget al (2013) Discovery of small molecule inhibitors of the TLR1-TLR2 complex. Angew.Chem.Int.Ed.Engl. 51 12246. PMID: 22969053. |